Logo Logo
  • Home
  • Publications
  • Meet Our Team
  • Contact

More Info

  • Email papinlab@virgina.edu
  • Phone Office: (434) 924-8195 Computational lab: (434) 982-6267 Wet lab: (434) 924-8640
  • Location 415 Lane Road, Room 2041 Charlottesville, VA 22903

Related Links

  • PubMed
  • UVA Engineering

Connect With Us

Inferring Metabolic Mechanisms of Interaction within a Defined Gut Microbiota

  • Home
  • Blog Details
September 10 2018
  • Published Works

Cell Syst. 2018 Sep 26;7(3):245-257.e7. doi: 10.1016/j.cels.2018.08.003. Epub 2018 Sep 5.

ABSTRACT

The diversity and number of species present within microbial communities create the potential for a multitude of interspecies metabolic interactions. Here, we develop, apply, and experimentally test a framework for inferring metabolic mechanisms associated with interspecies interactions. We perform pairwise growth and metabolome profiling of co-cultures of strains from a model mouse microbiota. We then apply our framework to dissect emergent metabolic behaviors that occur in co-culture. Based on one of the inferences from this framework, we identify and interrogate an amino acid cross-feeding interaction and validate that the proposed interaction leads to a growth benefit in vitro. Our results reveal the type and extent of emergent metabolic behavior in microbial communities composed of gut microbes. We focus on growth-modulating interactions, but the framework can be applied to interspecies interactions that modulate any phenotype of interest within microbial communities.

PMID:30195437 | PMC:PMC6166237 | DOI:10.1016/j.cels.2018.08.003

Previous Post Next Post

Recent Posts

  • Metabolic modeling of sex-specific tissue predicts mechanisms of differences in toxicological responses
  • Identifying metabolic shifts in Crohn’s disease using’ omics-driven contextualized computational metabolic network models
  • Ten simple rules for launching an academic research career
  • Metabolic Network Models of the Gardnerella Pangenome Identify Key Interactions with the Vaginal Environment
  • Enterococci enhance Clostridioides difficile pathogenesis
Logo

Computational Systems Biology Laboratory; The research group of Dr. Jason Papin in the Department of Biomedical Engineering at the University of Virginia.

Related Links

  • PubMed
  • UVA Engineering

Contact Info

The research group of Dr. Jason Papin in the Department of Biomedical Engineering at the University of Virginia

  • Email: papinlab@virginia.edu
  • Phone (434) 924-8195

  • Home
  • Publications
  • Meet Our Team
  • Contact