Logo Logo
  • Home
  • Publications
  • Meet Our Team
  • Contact

More Info

  • Email papinlab@virgina.edu
  • Phone Office: (434) 924-8195 Computational lab: (434) 982-6267 Wet lab: (434) 924-8640
  • Location 415 Lane Road, Room 2041 Charlottesville, VA 22903

Related Links

  • PubMed
  • UVA Engineering

Connect With Us

Biomedical applications of genome-scale metabolic network reconstructions of human pathogens

  • Home
  • Blog Details
December 11 2017
  • Published Works

Curr Opin Biotechnol. 2018 Jun;51:70-79. doi: 10.1016/j.copbio.2017.11.014. Epub 2017 Dec 7.

ABSTRACT

The growing global threat of antibiotic resistant human pathogens has coincided with improved methods for developing and using genome-scale metabolic network reconstructions. Consequently, there has been an increase in the number of high-quality reconstructions of relevant human and zoonotic pathogens. Novel biomedical applications of pathogen reconstructions focus on three key aspects of pathogen behavior: the evolution of antibiotic resistance, virulence factor production, and host-pathogen interactions. New methods using these reconstructions aim to improve understanding of microbe pathogenicity and guide the development of new therapeutic strategies. This review summarizes the latest ways that genome-scale metabolic network reconstructions have been used to study human pathogens and suggests future applications with the potential to mitigate infectious disease.

PMID:29223465 | PMC:PMC5991985 | DOI:10.1016/j.copbio.2017.11.014

Previous Post Next Post

Recent Posts

  • Metabolic modeling of sex-specific tissue predicts mechanisms of differences in toxicological responses
  • Identifying metabolic shifts in Crohn’s disease using’ omics-driven contextualized computational metabolic network models
  • Ten simple rules for launching an academic research career
  • Metabolic Network Models of the Gardnerella Pangenome Identify Key Interactions with the Vaginal Environment
  • Enterococci enhance Clostridioides difficile pathogenesis
Logo

Computational Systems Biology Laboratory; The research group of Dr. Jason Papin in the Department of Biomedical Engineering at the University of Virginia.

Related Links

  • PubMed
  • UVA Engineering

Contact Info

The research group of Dr. Jason Papin in the Department of Biomedical Engineering at the University of Virginia

  • Email: papinlab@virginia.edu
  • Phone (434) 924-8195

  • Home
  • Publications
  • Meet Our Team
  • Contact