Computational Systems Biology Lab

Principal Investigator: Jason Papin Ph.D.

 

Our Mission

What do we do?

We aspire to tackle important challenges in the study of metabolic networks that underlie problems in human health & well-being. We perform experiments to understand the systems-level function of these cellular metabolic networks and we develop novel computational tools to integrate these high-throughput data in order to predict how cells respond to environmental & genetic perturbations. We perform further experiments to validate and improve these computational models. With increased predictive ability, we can gain an understanding of mechanisms of metabolism that are critical in public health and identify potential strategies and interventions. Our efforts in this research area are always guided by clear ethical principles.  As we engage in this research, we will make important advances in the health and well-being of society.

🚨🥳iTHRIV has the pleasure of announcing the next cohort of Scholars! Welcome Christine Ibilibo,@JiaRayYu1 @gumbo_amando @PRodriguezMD Rell Parker & Rose Nevill @SArmbrusterMD @AndrewBarros! https://t.co/Elanp5D8LZ @CarilionClinic @FralinBiomed @VaMdVetMed @uvahealthnews

I can't believe it's been almost two years since I last had a discussion with Jennie Reed. Not a day goes by that I don't miss walking into her office for a chat. The world is a lesser place without her smile. https://t.co/9gSgR3OIyl

Metabolic Network Analysis Helps Clarify Drivers of Virulence in C Difficile https://t.co/q4SBbqxOJd via @Contagion_Live

Load More...

The Papin Lab

Understanding biochemical networks will lead to revolutionary advances in medicine and biotechnology.

There is a pressing need for reconstructing and analyzing the biochemical networks that orchestrate cellular processes. Understanding how these biochemical networks function (and malfunction) will lead to revolutionary advances in medicine, biotechnology, and the understanding of fundamental biological processes.

The Computational Systems Biology Laboratory (CSBL) at the University of Virginia uses computational and experimental approaches to characterize biological systems relevant to human disease. In particular, we reconstruct integrated cellular networks and develop tools to analyze their properties. The analysis of these networks requires sophisticated computing capabilities, experimental methods, and mathematical techniques.

Thumb Thumb

Recent Publications

View some of the Papin Lab's most recent published works. A more complete list of our published works can be found below or by visiting Dr. Papin's PubMed page found on the Publications page.

View More

Fecal sphingolipids predict parenteral nutrition associated cholestasis in the neonatal intensive care unit

JPEN J Parenter Enteral Nutr. 2022 Mar 13. doi: 10.1002/jpen.2374. Online ahead of print.ABSTRACTBACKGROUND: Parenteral nutrition associated cholestasis (PNAC) in the neonatal intensive care unit (NICU) causes significant morbidity and associated healthcare costs. Laboratory detection of PNAC currently relies on elevated serum conjugated bilirubin levels in the aftermath of impaired bile flow. Here, we sought […]

Read More

Comparative analyses of parasites with a comprehensive database of genome-scale metabolic models

PLoS Comput Biol. 2022 Feb 23;18(2):e1009870. doi: 10.1371/journal.pcbi.1009870. eCollection 2022 Feb. ABSTRACT Protozoan parasites cause diverse diseases with large global impacts. Research on the pathogenesis and biology of these organisms is limited by economic and experimental constraints. Accordingly, studies of one parasite are frequently extrapolated to infer knowledge about another parasite, across and within genera. […]

Read More

Comparative analyses of parasites with a comprehensive database of geno-scale metabolic models

PLoS Comput Biol. 2022 Feb 23;18(2):e1009870. doi: 10.1371/journal.pcbi.1009870. Online ahead of print. ABSTRACT Protozoan parasites cause diverse diseases with large global impacts. Research on the pathogenesis and biology of these organisms is limited by economic and experimental constraints. Accordingly, studies of one parasite are frequently extrapolated to infer knowledge about another parasite, across and within […]

Read More
Location

415 Lane Road, Room 2041
Charlottesville, VA 22903

Contact Information

Office:
(434) 924-8195
Computational lab:
(434) 982-6267
Computational lab 2nd line:
(434) 982-6269
Wet lab:
(434) 924-8640

Send a Message

[email protected]